Publikationen Prof. Dr. med. Ingo Bechmann

Original- und Übersichtsarbeiten  |   Buchartikel

 

Original- und Übersichtsarbeiten (2008 2007 2006 2005 2004 2003 2002 2001 2000 1999-1997)

2009

Streit WJ, Braak H, Xue QS, Bechmann I (2009) Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol, 118: 475-485

2008

Färber K, Markworth S, Pannasch U, Nolte C, Prinz V, Kronenberg G, Gertz K, Endres M, Bechmann I, Enjyoji K, Robson SC, Kettenmann H (2008) The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. Glia 56: 331-341

Frank S, Burbach GJ, Bonin M, Walter M, Streit W, Bechmann I, Deller T (2008) TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia 56: 1438-1447

Hoche F, Seidel K, Brunt ER, Auburger G, Schöls L, Bürk K, de Vos RA, den Dunnen W, Bechmann I, Egensperger R, Van Broeckhoven C, Gierga K, Deller T, Rüb U (2008) Involvement of the auditory brainstem system in spinocerebellar ataxia type 2 (SCA2), type 3 (SCA3) and type 7 (SCA7). Neuropath Appl Neuro 34: 479-491

De Jong EK, de Haas AH; Brouwer N, van Weering HR Hensens M, Bechmann I, Pratley P, Wesseling E, Boddeke HW, Biber K (2008) Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3. J Neurochem 105: 1726-1736

Owens T, Bechmann I, Engelhardt B (2008) Perivascular spaces and the two steps to neuroinflammation. J Neuropath Exp Neur, 67: 1113-1121

Rami A, Bechmann I, Stehle JH (2008) Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog Neurobiol 85: 273-296

Rüb U, Brunt ER, Seidel K, Gierga K, Mooy CM, Kettner M, van Broeckhoven C, Bechmann I, La Spada AR, Schöls L, den Dunnen W, de Vos RA, Deller T (2008) Spinocerebellar ataxia type 7 (SCA7): widespread brain damage in an adult-onset patient with progressive visual impairments in comparison with an adult-onset patient without visual impairments. Neuropath Appl Neuro 34: 155-168

Wuerfel J, Haertle M, Waiczies H, Tysiak E, Bechmann I, Wernecke KD, Zipp F, Paul F (2008) Perivascular spaces--MRI marker of inflammatory activity in the brain? Brain 131: 2332-2340

Van Zwam M, Huizinga R, Melief MJ, Wierenga-Wolf AF, van Meurs M, Voerman JS, Biber KP, Boddeke HW, Höpken UE, Meisel C, Meisel A, Bechmann I, Hintzen RQ, 't Hart BA, Amor S, Laman JD, Boven LA (2008)  Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE. J Mol Med (published Online)

2007

Bechmann I, Galea I, Perry VH (2007) What is the blood-brain barrier (not)? Trends Immunol 28: 5-11

Braun JS, Hoffmann O, Schickhaus M, Freyer D, Dagand E, Bermpohl D, Mitchell TJ, Bechmann I, Weber JR (2007) Pneumolysin causes neuronal cell death through mitochondrial damage. Infect Immun 75: 4245-4254

Galea I, Bechmann I, Perry VH (2007) What is immune privilege (not)? Trends Immunol 28: 12-8

Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL (2007) Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med 13: 89-94

Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A (2007) TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brainn 130: 535-547

Lehnardt S, Wennekamp J, Freyer D, Liedtke C, Krueger C, Nitsch R, Bechmann I, Weber JR, Henneke P (2007) TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. J Immunol 179: 6134-6143

Lipp M, Brandt C, Dehghani F, Kwidzinski, Bechmann I (2007) PD-L1 (B7-H1) regulation in zones of axonal degeneration. Neurosci Lett 425: 156-161

Mutlu L, Brandt C, Kwidzinski E, Sawitzki B, Gimsa U, Mahlo J, Aktas O, Nitsch R, van Zwam M, Laman JD, Bechmann I (2007) Tolerogenic effect of fiber tract injury: Reduced EAE severity following entorhinal cortex lesion. Exp. Brain Res 178: 542-553

Deller T, Del Turco D, Rappert A, Bechmann I (2007) Structural reorganization of the dentate gyrus following entorhinal denervation: species differences between rat and mouse. Prog Brain Res 163: 501-528

Kwidzinski E, Bechmann I (2007) IDO expression in the brain: a double-edged sword. J Mol Med-Jmm 85: 1351-1359

2006

Goldmann J, Kwidzinski E, Brandt C, Mahlo J, Richter D, Bechmann I (2006) T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa. J Leukocyte Biol 80(4): 797-801

Lehnardt S, Henneke P, Lien E, Kasper DL, Volpe JJ, Bechmann I, Nitsch R, Weber JR, Golenbock DT, Vartanian T (2006) A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol 177: 583-592

Becher B, Bechmann I, Greter M (2006) Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain. J Mol Med 84: 532-543

2005

Dorr J, Roth K, Zurbuchen U, Deisz R, Bechmann I, Lehmann TN, Meier S, Nitsch R, Zipp F (2005) Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate. J Neuroimmunol 167: 204-209

Kwidzinski E, Bunse J, Aktas O, Zipp F, Nitsch R & Bechmann I: Indolamine 2,3-dioxygenase (IDO) is expressed in the CNS and downregulates autoimmune inflammation. Faseb J 19: 1347-1349

Aktas O, Smorodchenko A, Brocke S, Infante-Duarte C, Prozorovski T, Meier S, Osmanova V, Pohl E, Beyer M, Bechmann I, Nitsch R & Zipp F: Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron 46: 421-432

Bermpohl D, Halle A, Freyer D, Dagand E, Schröder NW, Bechmann I, Schröter NW, Weber JR (2005) Bacterial programmed cell death of cerebral endothelial cells: Dual death pathways. J Clin Invest 115:1607-15

Bechmann I, Goldmann J, Kovac AD., Kwidzinski E, Simburger E, Naftolin F, Dirnagl U, Nitsch R & Priller J (2005) Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia. Faseb J 19: 647-649

Bechmann, I (2005) Failed CNS regeneration: a downside of immune privilege? Neuromol Med 7: 217-228

2004

Seiffert E, Dreier JP, Ivens S, Bechmann I, Tomkins O, Heinemann U & Friedman A (2004) Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. J Neurosci 24: 7829-7836

Rappert A*, Bechmann I*, Pivneva T, Mahlo J, Biber K, Nolte C, Kovac A.D, Gerard C, Boddeke HW, Nitsch R & Kettenmann H (2004) CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion. J Neurosci 24: 8500-8509

Oren A., Falk K, Rotzschke O, Bechmann I, Nitsch R & Gimsa U (2004) Production of neuroprotective NGF in astrocyte-T helper cell cocultures is upregulated following antigen recognition. J Neuroimmunol 149: 59-65

Kovac A.D, Kwidzinski E, Heimrich B, Bittigau P, Deller T, Nitsch R & Bechmann I (2004) Entorhinal cortex lesion in the mouse induces transsynaptic death of perforant path target neurons. Brain Pathol 14: 249-257

Gimsa U, ORen A., Pandiyan P, Teichmann D, Bechmann I, Nitsch R & Brunner-Weinzierl MC (2004) Astrocytes protect the CNS: antigen-specific T helper cell responses are inhibited by astrocyte-induced upregulation of CTLA-4 (CD152). J Mol Med-Jmm 82: 364-372

DeVry CG, Valdez M, Gao L, Wang J, Kotsch K, Volk HD, Bechmann I, Buelow R & Iyer S (2004) RDP58, a novel immunomodulatory peptide, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalomyelitis. J Neuroimmunol 152: 33-43

Brinks H, Conrad S, Vogt J, Oldekamp J, Sierra A., Deitinghoff L, Bechmann I, Alvarez-Bolado G, Heimrich B, Monnier PP, Mueller BK & Skutella T (2004) The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus. J Neurosci 24: 3862-3869

Mutlu LK, Woiciechowsky C & Bechmann I (2004) Inflammatory response after neurosurgery. Best Pract Res Clin Anaesthesiol 18: 407-424

2003

Wiesener MS, Jurgensen JS, Rosenberger C, Scholze CK, Horstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA., Pugh CW, Ratcliffe PJ, Bachmann S, Maxwell PH & Eckardt KU (2003) Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.Faseb J 17: 271-273

Wehner T, Bontert M, Eyupoglu I, Prass K, Prinz M, Klett FF, Heinze M, Bechmann I, Nitsch R, Kirchhoff F, Kettenmann H, Dirnagl U & Priller J (2003) Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. J Neurosci 23: 5004-5011

Eyupoglu IY., Bechmann I* & Nitsch R* (2003) Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus. Faseb J 17: 1110-1111

Kwidzinski E, Mutlu LK, Kovac AD, Bunse J, Goldmann J, Mahlo J, Aktas O, Zipp F, Kamradt T, Nitsch R & Bechmann I (2003) Self-tolerance in the immune privileged CNS: lessons from the entorhinal cortex lesion model. J Neural Transm-Supp 65: 29-49

Kamradt T, Hansen G, Bechmann I & Burmester GR (2003) [T-cell tolerance and autoimmunity] Internist 44: 146-152

2002

Wolf SA., Fisher J, Bechmann I, Steiner B, Kwidzinski E & Nitsch R (2002) Neuroprotection by T-cells depends on their subtype and activation state. J Neuroimmunol 133: 72-80

Kovac AD., Grammig J, Mahlo J, Steiner B, Roth K, Nitsch R & Bechmann I (2002) Comparison of neuronal density and subfield sizes in the hippocampus of CD95L-deficient (gld), CD95-deficient (lpr) and nondeficient mice. Eur J Neurosci 16: 159-163

Horvath B, Spies C, Horvath G, Kox WJ, Miyamoto S, Barry S, Warden CH, Bechmann I, Diano S, Heemskerk J & Horvath TL (2002) Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochem Pharmacol 64: 369-374

Dorr J*, Bechmann I*, Waiczies S, Aktas O, Walczak H, Krammer PH, Nitsch R & Zipp F (2002) Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci 22: RC209

Coy JF, Wiemann S, Bechmann I, Bachner D., Nitsch R, Kretz O, Christiansen H & Poustka A (2002) Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. Gene 290: 73-94

Bechmann I, Steiner B, Gimsa U, Mor G, Wolf S, Beyer M, Nitsch R & Zipp F (2002) Astrocyte-induced T cell elimination is CD95 ligand dependent. J Neuroimmunol 132: 60-65

Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R & Horvath TL (2002) Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol 64: 363-367

2001

Wolf SA, Gimsa U, Bechmann I & Nitsch R (2001) Differential expression of costimulatory molecules B7-1 and B7-2 on microglial cells induced by Th1 and Th2 cells in organotypic brain tissue. Glia 36: 414-420

Van Landeghem FK, Stover JF, Bechmann I, Bruck W, Unterberg A, Bührer C & Von Deimling A (2001) Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia 35: 167-179

Ullrich O, Diestel A, Bechmann I, Homberg M, Grune T, Hass R & Nitsch R (2001) Turnover of oxidatively damaged nuclear proteins in BV-2 microglial cells is linked to their activation state by poly-ADP-ribose polymerase. Faseb J 15: 1460-1462

Priller J, Flugel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernandez-Klett F, Prass K, Bechmann I, de Boer BA, Frotscher M, Kreutzberg GW, Persons D.A & Dirnagl U (2001) Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med 7: 1356-1361

Gimsa U, Wolf SA, Haas D., Bechmann I & Nitsch R (2001) Th2 cells support intrinsic anti-inflammatory properties of the brain. J Neuroimmunol 119: 73-80

Bechmann I, Priller J, Kovac A, Bontert M, Wehner T, Klett FF, Bohsung J, Stuschke M, Dirnagl U & Nitsch R (2001) Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages. Eur J Neurosci 14: 1651-1658

Bechmann I, Peter S, Beyer M, Gimsa U & Nitsch R (2001) Presence of B7--2 (CD86) and lack of B7--1 (CD(80) on myelin phagocytosing MHC-II-positive rat microglia is associated with nondestructive immunity in vivo. Faseb J 15: 1086-1088

Bechmann I, Kwidzinski E, Kovac AD., Simburger E, Horvath T, Gimsa U, Dirnagl U, Priller J & Nitsch R (2001) Turnover of rat brain perivascular cells. Exp Neurol 168: 242-249

Bechmann I & Nitsch R (2001) Plasticity following lesion: help and harm from the immune system. Restor Neurol Neuros 19: 189-198

2000

Nitsch R*, Bechmann I*, Deisz RA, Haas D., Lehmann TN, Wendling U & Zipp F (2000) Human brain-cell death induced by tumour-necrosis-factor-relatedapoptosis-inducing ligand (TRAIL) Lancet 356: 827-828

Gimsa U, Peter SV, Lehmann K, Bechmann I & Nitsch R (2000) Axonal damage induced by invading T cells in organotypic central nervoussystem tissue in vitro: involvement of microglial cells. Brain Pathol 10: 365-377

Diano S, Urbanski HF, Horvath B, Bechmann I, Kagiya A, Nemeth G, Naftolin F, Warden CH & Horvath TL (2000) Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary. Endocrinology 141: 4226-4238

Bechmann I, Lossau S, Steiner B, Mor G, Gimsa U & Nitsch R (2000) Reactive astrocytes upregulate fas (CD95) and fas ligand (CD95L)expression but do not undergo programmed cell death during the course ofanterograde degeneration. Glia 32: 25-41

Kobbert C, Apps R, Bechmann I, Lanciego JL, Mey J & Thanos S (2000) Current concepts in neuroanatomical tracing. Prog Neurobiol 62: 327-351

Bechmann I & Nitsch R (2000) Involvement of non-neuronal cells in entorhinal-hippocampal reorganization following lesions. Ann Ny Acad Sci 911: 192-206

1997 - 1999

Bechmann I, Mor G, Nilsen J, Eliza M, Nitsch R & Naftolin F (1999) FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier. Glia 27: 62-74

Mor G, Nilsen J, Horvath T, Bechmann I, Brown S, Garcia-Segura LM & Naftolin F (1999) Estrogen and microglia: A regulatory system that affects the brain. J Neurobiol 40: 484-496

Kluge A, Hailer NP, Horvath TL, Bechmann I & Nitsch R (1998) Tracing of the entorhinal-hippocampal pathway in vitro. Hippocampus 8: 57-68

Horvath TL, Bechmann I, Naftolin F, Kalra SP & Leranth C (1997) Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res 756: 283-286

Bergmann M, Post A, Rittel I, Bechmann I & Nitsch R (1997) Expression of synaptophysin in sprouting neurons after entorhinal lesion in the rat. Exp Brain Res 117: 80-86

Bechmann I & Nitsch R (1997) Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion: a light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique. Glia 20: 145-154

Bechmann I & Nitsch R (1997) Identification of phagocytic glial cells after lesion-induced anterograde degeneration using double-fluorescence labeling: combination of axonal tracing and lectin or immunostaining. Histochem Cell Biol 107: 391-397

 

Buchartikel

Bechmann I, Nitsch R (erscheint 2009) Gliazellen und Neurone. Bechmann I: Innerer und äußerer Liquorraum und Hirnhäute. In: Lehrbuch der Anatomie, Zilles & Tillmann

Bechmann I, Krueger M (2008) Pericytes. In: Central nervous system diseases and inflammation, Springer- Verlag, New York, pp 33-43

Bechmann I, Rappert A, Priller J, Nitsch R (2007) The microglial component. In: Blood Brain Barrier Interfaces, Spray & Dermietze

Bechmann I (2005) Mein Ich und mein Gehirn. Oder: Alles ist Sprache. In: Musarum sedes, Goslar & Tasler, pp 273-84

Bechmann I (2005) Brain. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, Ganten & Ruckpaul

Bechmann I, Nitsch R (2005) Interaction of glial cells with monocytes In: Neuroglia (2nd Edition), Kettenmann & Ransom, pp 302-312

Silva I, Nilsen J, Williams S, Bechmann I, Garcia-Segura LM, Mor G, Naftolin F (2003) Estrogen effects on microglia and the immune checkpoint proteins in the brain. In: Menopause. State of the Art – in research and management, Schneider, pp 186-190

Bechmann I, Nitsch R (2002) Zentrales Nervensystem. In: Anatomie des Menschen (17. völlig neu überarbeitete Auflage), Waldeyer, pp 355-549

 

 

geändert am 05. Oktober 2009  E-Mail: WebmasterK.Lang@em.uni-frankfurt.de

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